CD268 antibodies, mouse

CD268 antibodies, mouse

Clone: 7H22-E16 | Dilution: 1:10
Clone 7H22-E16 reacts with CD268, also known as B cell activation factor receptor (BAFF-R), a type III transmembrane TNF receptor family member. CD268 is expressed at high levels on resting B cells, at lower levels on activated B cells, and on a small subset of activated/memory T cells. BAFF, also known as BLys, mediates costimulatory responses in peripheral B and T cells. BAFF is a key regulator for B cell differentiation as well as survival and activation of peripheral B cell populations. Accordingly, CD268 appears to be particularly involved in the regulation of normal B cell survival and maturation, but also in the pathophysiology of aggressive B cell malignancies and autoimmune diseases.

Alternative names

TNFRSF13c, BR3, BAFFR, Bcmd, Bcmd-1, Lvis22

Technical specifications

  • Antigen: CD268
  • Clone: 7H22-E16
  • Isotype: rat IgG1κ
  • Isotype control: Rat IgG1 – isotype control antibodies
  • Alternative names of antigen: TNFRSF13c, BR3, BAFFR, Bcmd, Bcmd-1, Lvis22
  • Entrez Gene ID: 72049
  • Molecular mass of antigen [kDa]: 19
  • Distribution of antigen: B cells, leukocytes, lymphocytes, spleen, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin, FITC
  • Selected references

    1. Thompson, J. S. et al. (2001) BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293(5537): 2108-2111
    2. Yan, M. et al. (2001) Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr. Biol. 11(19): 1547-1552
    3. Ng, L. G. et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J. Immunol. 173(2): 807-817
    4. Ng, L. G. et al. (2006) BAFF costimulation of Toll-like receptor-activated B-1 cells. Eur. J. Immunol. 36(7): 1837-1846
Product options: 6
30 µg in 1 mL (1)
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130-102-553

CD268-PE, mouse

30 µg in 1 mL (1)
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130-102-500

CD268-APC, mouse

30 µg in 1 mL (1)
-
9 µg in 300 µL (1)
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30 µg in 1 mL (1)
-
30 µg in 1 mL (1)
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