CD21 antibodies, human

CD21 antibodies, human

Clone: REA940 | Dilution: 1:50
Clone REA940 recognizes the human CD21 antigen, a type I membrane glycoprotein. Expression of CD21 in humans is found on B cells, follicular dendritic cells, subsets of epithelial cells, and thymic T cells. The primary function attributed to CD21 has been to amplify the B cell receptor (BCR)–mediated signal transduction in response to antigen recognition. To enhance the BCR mediated activation, CD21 associates with CD19 and CD81 in a B cell–specific signal transduction complex, where interaction of BCR with CR2/CD19 amplifies the signals. In addition, CD21 serves as a receptor for split products of complement protein C3, the gp350/220 viral coat protein of the EBV and the immunoregulatory protein CD23.
Additional information: Clone REA940 displays negligible binding to Fc receptors.

Alternative names

CR2, C3dR, CR, CVID7, SLEB9

Technical specifications

  • Antigen: CD21
  • Clone: REA940
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CR2, C3dR, CR, CVID7, SLEB9
  • Entrez Gene ID: 1380
  • Molecular mass of antigen [kDa]: 111
  • Cross-reactivity: cow, dog, pig
  • Distribution of antigen: B cells, dendritic cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Biotin
  • Selected references

    1. Roberts, M. L. et al. (1996) Epstein—Barr virus binding to CD21, the virus receptor, activates resting B cells via an intracellular pathway that is linked to B cell infection. Virology 77: 3077-3085
    2. Braun, M. et al. (1998) Human B and T lymphocytes have similar amounts of CD21 mRNA, but differ in surface expression of the CD21 glycoprotein. Int. Immunol. 10: 1197-1202
    3. Cherukuri, A. et al. (2001) The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens. J. Immunol. 167: 163-172
    4. Barrington, R. A. et al. (2005) CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responses. J. Immunol. 175: 2589-2867
Product options: 10
130-115-609

CD21-FITC, human

for 30
tests
(1)
-
130-115-515

CD21-FITC, human

for 100
tests
(1)
-
130-115-610

CD21-PE, human

for 30
tests
(1)
-
130-115-516

CD21-PE, human

for 100
tests
(1)
-
130-115-611

CD21-APC, human

for 30
tests
(1)
-
130-115-517

CD21-APC, human

for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-

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