CD209 (DC-SIGN) antibodies, human

CD209 (DC-SIGN) antibodies, human

Clone: DCN47.5 | Dilution: 1:11
Clone DCN47.5 recognizes CD209 (Dendritic Cell Specific ICAM-3 Grabbing Non-integrin, DC-SIGN), a type II c-type lectin expressed in dermal and mucous tissue, lymphoid tissue such as tonsil, lymph node, spleen, and on monocyte-derived DCs (MoDCs). It is not expressed on DC subsets in peripheral blood, except for a subpopulation of CD14
+
cells with a DC-like phenotype.
DC-SIGN acts as an adhesion receptor to facilitate interactions between DCs and T cells or DCs and endothelial cells. In addition, it serves as an antigen receptor mediating internalization of ligands for antigen presentation, binding virus such as HIV, HCMV, or Ebola as well as parasites, bacteria, or yeast.
HIV-1 uses this feature of DC-SIGN for efficient in
-trans
infection of CD4
+
T cells.

Alternative names

CDSIGN, CLEC4L, DC-SIGN

Technical specifications

  • Antigen: CD209 (DC-SIGN)
  • Clone: DCN47.5
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CDSIGN, CLEC4L, DC-SIGN
  • Entrez Gene ID: 30835
  • Molecular mass of antigen [kDa]: 46
  • Distribution of antigen: dendritic cells, endothelial cells, macrophages, skin, spleen
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBlue, PE-Vio770, APC-Vio770, Biotin, pure, FITC, PE, APC
  • Selected references

    1. Koppel, E. A. et al. (2005) Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation. Cell. Microbiol. 7: 157-165
    2. Geijtenbeek, T. B. et al. (2000) Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 100: 575-585
Product options: 14
for 30
tests
(1)
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for 100
tests
(1)
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for 30
tests
(1)
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for 100
tests
(1)
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for 30
tests
(1)
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for 100
tests
(1)
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for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 100
tests
(1)
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100 µg in 1 mL
-

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