CD151 antibodies, human

CD151 antibodies, human

Clone: REA265 | Dilution: 1:11
Clone REA265 recognizes the CD151 antigen, a 29 kDa cell surface glycoprotein, which is also known as platelet-endothelial tetraspan antigen 3 (PETA-3) or tetraspanin-24 (Tspan-24). Like other tetraspanin family members, CD151 contains four hydrophobic transmembrane domains, two short cytoplasmic tails, and one small and one large extracellular loop. CD151 is expressed by many different cell types such as platelets, immature hematopoietic cells, megakaryocytes, keratinocytes, epithelial cells, muscle cells, Schwann cells, vascular endothelium, as well as epithelial cells. It complexes with integrins and other transmembrane 4 superfamily proteins and is involved in cellular processes including cell adhesion and regulates integrin trafficking and function. CD151 enhances cell motility, invasion, and metastasis of tumor cells.
Additional information: Clone REA265 displays negligible binding to Fc receptors.

Alternative names

GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24

Technical specifications

  • Antigen: CD151
  • Clone: REA265
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24
  • Entrez Gene ID: 977
  • Molecular mass of antigen [kDa]: 28
  • Distribution of antigen: epithelial cells, platelets, keratinocytes, Schwann cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Karamatic, C. V. et al. (2004) CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin. Blood 104(8): 2217-2223
    2. Kohno, M. et al. (2002) CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase. Int. J. Cancer 97(3): 336-343
    3. Chernousov, M. A. et al. (2013) Tetraspanins are involved in Schwann cell-axon interaction. J. Neurosci. Res. 91(11): 1419-1428
Product options: 8
130-103-727

CD151-PE, human

for 30
tests
(1)
-
130-103-662

CD151-PE, human

for 100
tests
(1)
-
130-103-728

CD151-APC, human

for 30
tests
(1)
-
130-103-663

CD151-APC, human

for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-

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