CD122 (IL-2Rβ) antibodies, mouse

CD122 (IL-2Rβ) antibodies, mouse

Clone: TM-β1 | Dilution: 1:10
The monoclonal antibody TM-ß1 recognizes the murine CD122 70–75 kDa cell surface glycoprotein, also known as interleukin-2 receptor beta chain (IL-2Rβ). CD122 is constitutively expressed on mouse NK cells and at a lower level on subsets of T cells, B cells, monocytes, and macrophages. CD122 can associate with the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25), resulting in intermediate or high affinity IL-2 receptor complexes. CD122 expression levels can be upregulated by activation. The TM-β1 antibody interferes with binding of IL-2 to the receptor and can be used to deplete CD122
+
cells.

Alternative names

IL2RB, IL-15Rbeta, Il-2/15Rbeta, Il-2Rbeta, p70, IL-2Rβ

Technical specifications

  • Antigen: CD122 (IL-2Rβ)
  • Clone: TM-β1
  • Isotype: rat IgG2bκ
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: IL2RB, IL-15Rbeta, Il-2/15Rbeta, Il-2Rbeta, p70, IL-2Rβ
  • Entrez Gene ID: 16185
  • Molecular mass of antigen [kDa]: 58
  • Distribution of antigen: B cells, macrophages, monocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, Biotin, FITC
  • Selected references

    1. Tanaka, T. et al. (1991) A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL- 4 J. Immunol. 147: 2222-2228
    2. Tang, Y. et al. (2011) Emergence of NK cell progenitors and functionally competent NK cell lineage subsets in the early mouse embryo. Blood 120: 63-75
    3. Taniguchi, T. et al. (1993) The IL-2/IL-2 receptor system: a current overview. Cell 73(1): 5-8
    4. Malek, T. R. et al. (1995) Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits. J. Interferon Cytokine Res. 15(5): 447-454
    5. Nishikawa, Y. et al. (2010)
      Roles of CD122
      +
      cells in resistance against
      Neospora caninum
      infection in a murine model.
      J. Vet. Med. Sci. 72(10): 1275-1282
Product options: 8
30 µg in 1 mL (1)
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30 µg in 1 mL (1)
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30 µg in 1 mL (1)
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9 µg in 300 µL (1)
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30 µg in 1 mL (1)
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9 µg in 300 µL (1)
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30 µg in 1 mL (1)
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30 µg in 1 mL (1)
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