CD107b antibodies, mouse

CD107b antibodies, mouse

Clone: M3/84 | Dilution: 1:10
Clone M3/84 recognizes the mouse CD107b antigen, a highly glycosylated 110 kD Single-pass type I membrane protein also known as Lysosome-associated membrane protein-2 (LAMP-2) or Mac-3 antigen. It is widely located in lysosomal membranes and the plasma membrane of macrophages and some myeloid cell lines. Under certain circumstances, e.g., after platelet activation, during granulocytic differentiation and activation, in malignant carcinoma cells, and in cytotoxic T lymphocytes, it is also found at the cell surface. CD107b has been described as a receptor for the selective import and degradation of cytosolic proteins in the lysosome, or chaperone-mediated autophagy.

Alternative names

LAMP-2, LGP-B, Lamp II, Mac3

Technical specifications

  • Antigen: CD107b
  • Clone: M3/84
  • Isotype: rat IgG1κ
  • Isotype control: Rat IgG1 – isotype control antibodies
  • Alternative names of antigen: LAMP-2, LGP-B, Lamp II, Mac3
  • Entrez Gene ID: 16784
  • Molecular mass of antigen [kDa]: 43
  • Distribution of antigen: macrophages, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, APC-Vio770, PerCP-Vio700
  • Selected references

    1. Tanaka, Y. et al. (2000) Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 406(6798): 902-906
    2. Cha, Y. et al. (1990) The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. J. Biol. Chem. 265(9): 5008-5013
    3. Asaoka, Y. et al. (2013) Immunohistochemistry of LAMP-2 and adipophilin for phospholipidosis in liver and kidney in ketoconazole-treated mice. Exp. Toxicol. Pathol. 65(6): 817-823
Product options: 10
9 µg in 300 µL (1)
-
30 µg in 1 mL (1)
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130-106-364

CD107b-PE, mouse

9 µg in 300 µL (1)
-
130-106-290

CD107b-PE, mouse

30 µg in 1 mL (1)
-
9 µg in 300 µL (1)
-
30 µg in 1 mL (1)
-
9 µg in 300 µL (1)
-
30 µg in 1 mL (1)
-
9 µg in 300 µL (1)
-
30 µg in 1 mL (1)
-

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