Anti-PAX-6 antibodies, human

Anti-PAX-6 antibodies, human

Clone: REA507 | Dilution: 1:11
Clone REA507 recognizes the human paired box protein PAX-6 antigen, a member of the paired box (PAX) gene family whose protein products are transcription factors involved in development. During organogenesis, PAX-6 is required for establishment of various progenitor subtypes within the central nervous system, eye, and pancreas. PAX-6 expression is maintained in a variety of cell types within each organ. PAX-6 is abundantly expressed during patterning of the optic vesicles and during specification and differentiation of the retinal pigmented epithelium. Defects in PAX-6 are responsible for various eye malformations including aniridia and Peters' anomaly.
Additional information: Clone REA507 displays negligible binding to Fc receptors.

Alternative names

AN, Oculorhombin, D11S812E, FVH1, MGDA, WAGR, AN2

Technical specifications

  • Antigen: PAX-6
  • Clone: REA507
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: AN, Oculorhombin, D11S812E, FVH1, MGDA, WAGR, AN2
  • Entrez Gene ID: 5080
  • Molecular mass of antigen [kDa]: 47
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, pure
  • Selected references

    1. Ton, C. C. et al. (1991) Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region. Cell 67(6): 1059-1074
    2. Klimova, L. et al. (2014) Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development 141(6): 1292-1302
    3. Ouyang, H. et al. (2014) WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. Nature 511(7509): 358-361
Product options: 3
for 30
tests
(1)
-
for 100
tests
(1)
-
100 µg in 1 mL
-

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3 products available