Anti-NKG2A/C/E antibodies, mouse

Anti-NKG2A/C/E antibodies, mouse

Clone: REA1100 | Dilution: 1:50
Clone REA1100 recognizes the mouse NKG2A, NKG2C, and NKG2E antigen on a subset of natural killer (NK) and NK-T cells in most mouse strains, for example, AKR/J, BALB/c, C3H/He,C57BL/6, CBA/J, DBA/1, FVB/N, 129/Sv, NOD, SWR, and most DBA/2 substrains, but not DBA/2J. The C-type lectin-like NKG2 receptors form heterodimers of CD94 and one of several NKG2 family members, i.e., NKG2A (CD159a), NKG2C (CD159c), or NKG2E. CD94/NKG2 receptors monitor classical class I expression indirectly by means of the recognition of classical class I signal peptides. These signal peptides are processed to a nonameric peptide called Qdm that is presented to CD94/NKG2
+
NK cells by a non-classical MHC class I molecule called Qa-1. CD94/NKG2 receptors equip NK cells with the capacity to detect cells with abnormal MHC class I expression, such as often results from viral infection or transformation.
Additional information: Clone REA1100 displays negligible binding to Fc receptors.

Alternative names

CD159a, CD159c, CD159e, NKG2A, KLRC1, NKG2C1, KLRC2, NKG2E, KLRC3

Technical specifications

  • Antigen: NKG2A/C/E
  • Clone: REA1100
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CD159a, CD159c, CD159e, NKG2A, KLRC1, NKG2C1, KLRC2, NKG2E, KLRC3
  • Entrez Gene ID: 16641
  • Molecular mass of antigen [kDa]: 28
  • Distribution of antigen: NK cells, NKT cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, VioBright 515
  • Selected references

    1. Lohwasser, S. et al. (1999) Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells. Eur. J. Immunol. 29(3): 755-761
    2. Silver, E. T. et al. (1999) Molecular cloning of mouse NKG2A and C. Immunogenetics 49(7-8): 727-730
    3. Foley, B. et al. (2012)
      Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C
      +
      natural killer cells with potent function.
      Blood 119(11): 2665-2674
Product options: 9
30 µg in 200 µL (1)
-
150 µg in 1 mL (1)
-
30 µg in 200 µL (1)
-
30 µg in 200 µL (1)
-
150 µg in 1 mL (1)
-
30 µg in 200 µL (1)
-
30 µg in 200 µL (1)
-
30 µg in 200 µL (1)
-
150 µg in 1 mL (1)
-