Anti-NK1.1 antibodies, mouse

Anti-NK1.1 antibodies, mouse

Clone: REA1162 | Dilution: 1:50
Clone REA1162 recognizes the mouse NK1.1 antigen, a single-pass type II membrane protein also known as CD161 or killer cell lectin-like receptor subfamily B member 1. NK1.1 is expressed by natural killer cells and a subset of T cells in the mouse strains C57BL/6, FVB/N, and NZB, but not in the mouse strains AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. It plays a stimulatory role on natural killer cells cytotoxicity. Activation by cross-linking of the receptor induces Ca
2+
mobilization and interferon-gamma production.
Additional information: Clone REA1162 displays negligible binding to Fc receptors.

Alternative names

NKR-P1 40, CD161c, Ly-55c, NK1.1, NKR-P1.9, NKR-P1C

Technical specifications

  • Antigen: NK1.1
  • Clone: REA1162
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: NKR-P1 40, CD161c, Ly-55c, NK1.1, NKR-P1.9, NKR-P1C
  • Entrez Gene ID: 17059
  • Molecular mass of antigen [kDa]: 25
  • Distribution of antigen: NK cells, T cells, NKT cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Giorda, R. et al. (1992) Genomic structure and strain-specific expression of the natural killer cell receptor NKR-P1. J. Immunol. 149(6): 1957-1963
    2. Stenström, M. et al. (2005) Natural killer T-cell populations in C57BL/6 and NK1.1 congenic BALB.NK mice-a novel thymic subset defined in BALB.NK mice. Immunology 114(3): 336-345
    3. Ruiz, A. L. et al. (2014)
      NK1.1
      +
      CD8
      +
      T cells escape TGF-β control and contribute to early microbial pathogen response.
      Nat Commun 5: 5150
Product options: 9
30 µg in 200 µL (1)
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150 µg in 1 mL (1)
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30 µg in 200 µL (1)
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30 µg in 200 µL (1)
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30 µg in 200 µL (1)
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30 µg in 200 µL (1)
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30 µg in 200 µL (1)
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150 µg in 1 mL (1)
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30 µg in 200 µL (1)
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