Anti-LIF antibodies, human

Anti-LIF antibodies, human

Clone: REA350 | Dilution: 1:10
Clone REA350 recognizes the human leukemia inhibitory factor (LIF) antigen, a secreted variably glycosylated 180 amino acid protein also known as melanoma-derived lipoprotein lipase inhibitor (MLPLI). LIF is produced by a variety of cells including activated T cells and macrophages, myeloid cells, fibroblasts, liver, heart, and melanoma cells. It affects cell growth by inhibiting differentiation. Other properties attributed to the cytokine include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Additional information: Clone REA350 displays negligible binding to Fc receptors.

Alternative names

CDF, DIA, HILDA, MLPLI, LIF, HSF III, D factor, Emfilermin

Technical specifications

  • Antigen: LIF
  • Clone: REA350
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CDF, DIA, HILDA, MLPLI, LIF, HSF III, D factor, Emfilermin
  • Entrez Gene ID: 3976
  • Molecular mass of antigen [kDa]: 20
  • Distribution of antigen: embryonic germ cells, ES and iPS cells, myeloid cells, fibroblasts, liver, heart, T cells, macrophages, melanoma
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Moreau, J. F. et al. (1988) Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336(6200): 690-692
    2. Martello, G. et al. (2013) Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor. EMBO J. 32(19): 2561-2574
    3. Smith, A. G. (2001) Embryo-derived stem cells: of mice and men. Annu. Rev. Cell Dev. Biol. 17: 435-462
Product options: 4
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for 30
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for 100
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