Anti-iNKT antibodies, human

Anti-iNKT antibodies, human

Clone: REA1054 | Dilution: 1:50
Clone REA1054 recognizes human iNKT cells. Natural killer T (NKT) cells represent a distinct lymphocyte population that co-expresses T cell and NK cell surface markers. A subset of human NKT cells, referred to as iNKT cells, expresses an invariant TCR α-chain with certain TCR β-chains (Vα24-Jα18 combined with Vβ11). The iNKT cells are implicated in immunoregulatory processes such as tolerance, host defense, and tumor surveillance.
Additional information: Clone REA1054 displays negligible binding to Fc receptors.

Alternative names

TCR Vα24-JαQ, TCR Va24-JαQ

Technical specifications

  • Antigen: iNKT
  • Clone: REA1054
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TCR Vα24-JαQ, TCR Va24-JαQ
  • Entrez Gene ID: 28659, 28747, 28582, 28581, 933
  • Molecular mass of antigen [kDa]: 93
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: NKT cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, Biotin
  • Selected references

    1. Montoya, J. C. et al. (2007) Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11. Immunology 122: 1-14
    2. Exley, M. et al. (2008) Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR α-chain CDR3 loop. Eur. J. Immunol. 38: 1756-1766
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for 30
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for 100
tests
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for 30
tests
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-
for 100
tests
(1)
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