Anti-HLA-A2 A28 antibodies, human

Anti-HLA-A2 A28 antibodies, human

Clone: REA142 | Dilution: 1:11
Clone REA142 recognizes HLA A2 and HLA A28, class I human leukocyte antigens (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA142 displays negligible binding to Fc receptors.

Alternative names

HLA-A

Technical specifications

  • Antigen: HLA-A2, A28
  • Clone: REA142
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HLA-A
  • Entrez Gene ID: 3105
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: B cells, T cells, dendritic cells, epithelial cells, lymphocytes, granulocytes, leukocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169
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for 30
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for 100
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for 30
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for 100
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for 30
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for 100
tests
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