Anti-Helios antibodies, human and mouse

Anti-Helios antibodies, human and mouse

Clone: REA829 | Dilution: 1:50
Clone REA829 recognizes mouse and human Helios, which is a zinc-finger transcription factor of the Ikaros family. As well as Ikaros and Aiolos, Helios functions as an important regulator of lymphoid development and differentiation and is involved in the control of gene expression. Helios is found on the earliest haematopoietic sites of the embryo, in adult haemopoietic stem cells, and on regulatory T cells.
Additional information: Clone REA829 displays negligible binding to Fc receptors.

Alternative names

IKZF2, ANF1A2, ZNF1A2, ZNFN1A2

Technical specifications

  • Antigen: Helios
  • Clone: REA829
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IKZF2, ANF1A2, ZNF1A2, ZNFN1A2
  • Entrez Gene ID: 22807
  • Cross-reactivity: rat
  • Distribution of antigen: T cells, hematopoietic stem cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615
  • Selected references

    1. Kelley, C. M. et al. (1998) Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr. Biol. 8(9): 508-515
    2. Rebollo, A. et al. (2003) Ikaros, Aiolos and Helios: Transcription regulators and lymphoid malignancies. Immunol. Cell Biol. 81: 171-175
    3. Thornton, A. M. et al. (2010)
      Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3
      +
      T regulatory cells.
      Curr. Biol. 184: 3433-3441
    4. Gottschalk, R. A. et al. (2012)
      Expression of Helios in peripherally induced Foxp3
      +
      regulatory T cells.
      J. Immunol. 188: 976-980
Product options: 8
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for 100
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for 30
tests
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-
for 100
tests
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