Anti-GITRL antibodies, human

Anti-GITRL antibodies, human

Clone: REA841 | Dilution: 1:50
Clone REA841 recognizes the human GITRL, also known as the ligand for GITR (glucocorticoid-induced TNF receptor superfamily-related protein) and also called AITR (activation-inducible TNF receptor superfamily-related protein). GITRL, a type II membrane protein and a member of the TNF superfamily, is highly expressed in small intestine, ovary, testis, kidney, and endothelial cells. GITRL is not found in resting or stimulated T cells, B cells, or peripheral blood mononuclear cells (PBMCs). After stimulation by bacterial lipopolysaccharides (LPS), GITRL is upregulated. GITR and GITRL might play an important role for interactions between activated T lymphocytes and endothelial cells. Furthermore, overexpression on monocyte-derived DC enhances their capacity to induce antigen-specific T cell responses.
Additional information: Clone REA841 displays negligible binding to Fc receptors.

Alternative names

hGITRL, GITR Ligand, GITR-L, AITR Ligand, AITRL, AITR-L, TL6, TNFSF18

Technical specifications

  • Antigen: GITRL
  • Clone: REA841
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: hGITRL, GITR Ligand, GITR-L, AITR Ligand, AITRL, AITR-L, TL6, TNFSF18
  • Entrez Gene ID: 8995
  • Molecular mass of antigen [kDa]: 23
  • Distribution of antigen: ovary, testicle, kidney, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, VioBright 515, Biotin
  • Selected references

    1. Kwon, B. et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J. Biol. Chem. 274(10): 6056-6061
    2. Gurney, A. L. et al. (1999) Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 9: 215-218
    3. Shevach, E. M. et al. (2006) The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? Nat. Rev. Immunol. 6(8): 613-618
    4. Tuyaerts, S. et al. (2007)
      Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4
      +
      CD25
      +
      regulatory T cells.
      J. Leukoc. Biol. 82(1): 93-105
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