Anti-ERK2 antibodies, human and mouse

Anti-ERK2 antibodies, human and mouse

Clone: REA186 | Dilution: 1:11
Clone REA186 recognizes ERK2, a 42 KDa serine/threonine protein kinase, which participates in the MAPK signal transduction pathway. It is involved in regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription. ERK2 and the related kinase ERK1 are phosphorylated by kinases MEK1/2, leading to activation and nuclear translocation of ERKs, where they phosphorylate downstream targets, such as transcription factors including Ets, Elk, and c-Fos. ERK2 activation and mobilization is induced in reponse to several extracellular signals and engagement of receptors such as Tyr kinases (RTKs), G protein–coupled receptors (GPCRs), ion channels, and others. The ERK1/2 are dual specificity kinases and phosphorylate Ser or Thr residues neighbor to proline residue.
Additional Information: Clone REA186 displays negligible binding to Fc receptors.

Alternative names

MAPK1, ERK, ERK-2, ERT1, MAPK2, P42MAPK, p38, PRKM1, PRKM2

Technical specifications

  • Antigen: ERK2
  • Clone: REA186
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: MAPK1, ERK, ERK-2, ERT1, MAPK2, P42MAPK, p38, PRKM1, PRKM2
  • Entrez Gene ID: 5594
  • Molecular mass of antigen [kDa]: 41
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected references

    1. Gonzalez-Perez, G. and Lamousé-Smith, E. S. (2017)
      Gastrointestinal microbiome dysbiosis in infant mice alters peripheral CD8
      +
      T cell receptor signaling.
      Front Immunol 8(8): 265
    2. Roskoski, R. et al. (2012) ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol. Res. 66(2): 105-143
    3. Davis, R. J. et al. (1995) Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42(4): 459-467
    4. Lloyd, A. C. (2006) Distinct functions for ERKs? J. Biol. 5(5): 13
Product options: 6
for 30
tests
(1)
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for 100
tests
(1)
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for 30
tests
(1)
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for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
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