Anti-Embigin antibodies, mouse

Anti-Embigin antibodies, mouse

Clone: REA501 | Dilution: 1:50
Clone REA501 recognizes the mouse embigin antigen, a single-pass type I membrane protein, which is also known as teratocarcinoma glycoprotein Gp-70. Embigin is a developmentally expressed protein that is a member of the immunoglobulin superfamily class of cell adhesion molecules (CAMs). It is strongly expressed in mouse embryos between five and nine days of gestation but only weakly in adult organs. Embigin plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, embigin promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting the terminal Schwann cell number or their morphology.
Additional information: Clone REA501 displays negligible binding to Fc receptors.

Alternative names

Emb, Gp70

Technical specifications

  • Antigen: Embigin
  • Clone: REA501
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Emb, Gp70
  • Entrez Gene ID: 13723
  • Molecular mass of antigen [kDa]: 34
  • Distribution of antigen: hematopoietic stem cells, myeloid stem cells, T cells, Schwann cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Lain, E. et al. (2009) A novel role for embigin to promote sprouting of motor nerve terminals at the neuromuscular junction. J. Biol. Chem. 284(13): 8930-8939
    2. Huang, R. P. et al. (1993) Embigin, a member of the immunoglobulin superfamily expressed in embryonic cells, enhances cell-substratum adhesion. Dev. Biol. 155(2): 307-314
    3. Huang, R. P. et al. (1990) Developmentally regulated expression of embigin, a member of the immunoglobulin superfamily found in embryonal carcinoma cells. Differentiation 45(2): 76-83
Product options: 1
30 µg in 200 µL (1)
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