Anti-CX3CR1 antibodies, human

Anti-CX3CR1 antibodies, human

Clone: REA385 | Dilution: 1:11
Clone REA385 recognizes the human CX3C chemokine receptor 1 antigen, a 40 kDa G-protein–coupled multi-pass membrane protein also known as fractalkine receptor. CX3CR1 is expressed on natural killer (NK) cells, T cell subsets, monocytes/macrophages, dendritic cells (DCs), and some malignant epithelial cells. Binding of CX3CR1 to the membrane-bound form of the chemokine CX3CL1 promotes cell-cell adhesion, whereas the soluble form induces cell migration of CX3CR1-bearing cells such as monocytes, NK cells, T cells, DCs, and macrophages including microglia. CX3CR1 plays also an important role in the formation of transepithelial dendrites by intestinal DCs. Failure in the CX3CL1/CX3CR1 interaction may contribute to the development of several inflammatory diseases including atherosclerosis, psoriasis, rheumatoid arthritis, and experimental autoimmune myositis.
Additional information: Clone REA385 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: CX3CR1
  • Clone: REA385
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28, RBS11
  • Entrez Gene ID: 1524
  • Molecular mass of antigen [kDa]: 40
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    cynomolgus monkey (
    Macaca fascicularis
  • Distribution of antigen: NK cells, T cells, dendritic cells, macrophages, monocytes, epithelial cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Niess, J. H. et al. (2005)
      CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance.
      Science 307: 254-258
    2. Imai, T. et al. (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91: 521-530
    3. Raport, C. J. et al. (1995) The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues. Gene 163(2): 295-299
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