REAlease® CD166 Complexes, human

REAlease
®
CD166 Complexes
, human

Clone: REAL198 | Dilution: 1:50
Clone REAL198 is an antibody fragment derived from the full CD166 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL198 recognizes the human CD166 antigen, a single-pass type I membrane protein also known as activated leukocyte cell adhesion molecule (ALCAM). CD166, a member of the immunoglobulin superfamily and a ligand for the lymphocyte antigen CD6, mediates homophilic and heterophilic adhesion. It is expressed on activated leukocytes T cells, B cells, monocytes, hematopoietic stem cells (HSCs), metastasizing melanoma, neuronal cells, endothelial cells, hematopoiesis-supporting osteoblastic cell lines, and MSCs. CD166 expression is pathologically correlated with aggressive disease in a variety of cancers including melanoma, prostate, breast, ovarian, esophageal, and bladder cancers. It is also a universal functional marker of murine and human hematopoietic stem cells (HSC) and osteoblasts within the hematopoietic niche and it is involved in modulating HSC-niche interactions and HSC fate.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

ALCAM, MEMD

Technical specifications

  • Antigen: CD166
  • Clone: REAL198
  • Isotype control: REAL Control
  • Alternative names of antigen: ALCAM, MEMD
  • Distribution of antigen: T cells, B cells, monocytes, hematopoietic stem cells, melanoma, neuronal intestinal cells, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Degen, W. G. et al. (1998) MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). Am. J. Pathol. 152(3): 805-813
    2. Ni, C. et al. (2013) Prognostic value of CD166 expression in cancers of the digestive system: a systematic review and meta-analysis. PLoS One 8(8): e70958
    3. Chitteti, B. R. et al. (2014) CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche. Blood 124(4): 519-529
Product options: 3
for 30
tests
(1)
JPY 29,000
for 100
tests
(1)
JPY 68,000
for 100
tests
(1)
JPY 78,000

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