CD85j (ILT2) antibodies, human

CD85j (ILT2) antibodies, human

Clone: REA998 | Dilution: 1:50
Clone REA998 recognizes the human CD85j (ILT2) antigen, an inhibitory immunoreceptor of the immunoglobulin-like transcript (ILT) family. CD85j is a type I transmembrane protein with four extracellular Ig-like domains and four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail. The inhibitory signal is transmitted by recruiting SH2-containing protein tyrosine phosphatase-1 that dephosphorylates and inactivates downstream tyrosine kinases. Expression of CD85j is found on B cells, monocytes, dendritic cells, and subsets of natural killer (NK) and T cells. CD85j is known to bind classical and non-classical MHC class I molecules, human cytomegalovirus UL18 protein, and some HLA-C alleles, as ligands. Crosslinking of CD85j prevents activation of B cells, T cells, NK cells, macrophages, and downregulation of effector mechanisms, such as NK and T cells cytolytic functions.
Additional information: Clone REA998 displays negligible binding to Fc receptors.

Alternative names

LILRB1, ILT2, LIR-1, MIR-7

Technical specifications

  • Antigen: CD85j (ILT2)
  • Clone: REA998
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LILRB1, ILT2, LIR-1, MIR-7
  • Entrez Gene ID: 10859
  • Molecular mass of antigen [kDa]: 68
  • Distribution of antigen: B cells, dendritic cells, lymphocytes, monocytes, NK cells, T cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Biotin
  • Selected references

    1. Merlo, A. et al. (2005) Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes. Clin. Diagn. Lab. Immunol. 12: 705-712
    2. Borges, L. et al. (1997) A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. J. Immunol. 159: 5192-5196
    3. Morel, E. and Bellón, T. (2008) HLA Class I molecules regulate IFN-{gamma} production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j. J. Immunol. 181: 2368-2381
Product options: 10
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000

Related products

3 products available