CD85g (ILT7) antibodies, human

CD85g (ILT7) antibodies, human

Clone: REA100 | Dilution: 1:11
The clone REA100 recognizes human CD85g, also known as immunoglobulin-like transcript 7 (ILT7), a cell surface receptor which is specifically expressed on human plasmacytoid dendritic cells (PDCs). ILT7 associates with FcεR1γ chain through positively charged arginine residue located in the transmembrane domain to form a receptor complex. Cross-linking of ILT7 results in FcεR1γ-dependent activation of an ITAM-mediated signaling pathway, which negatively influences TLR7/9 induced type I IFN production. Cross-linking of ILT7 by REA100 monoclonal antibodies inhibits type I IFN production in human PDCs.
Additional information: Clone REA100 display negligible binding to Fc receptors.

Alternative names

LILRA4, ILT7

Technical specifications

  • Antigen: CD85g (ILT7)
  • Clone: REA100
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LILRA4, ILT7
  • Entrez Gene ID: 23547
  • Molecular mass of antigen [kDa]: 53
  • Distribution of antigen: dendritic cells, eosinophils, lymphocytes, macrophages, monocytes, neutrophils, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin, FITC
  • Selected references

    1. Cao, W. et al. (2006)
      Plasmacytoid
      dendritic cell–specific receptor ILT7–FcεRIγ inhibits Toll-like receptor–induced interferon production.
      J. Exp. Med. 203: 1399-1405
Product options: 8
for 100
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JPY 57,000
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JPY 24,000
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(1)
JPY 57,000
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JPY 25,000
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JPY 59,000
for 100
tests
(1)
JPY 49,000

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