CD53 antibodies, human

CD53 antibodies, human

Clone: REA259 | Dilution: 1:11
Clone REA259 recognizes the CD53 antigen, a 35–42 kDa type II transmembrane glycoprotein, which is also known as tetraspanin-25. CD53 is expressed on all leukocytes including plasma cells, but not on platelets, erythrocytes, and non-hematopoietic tissues. CD53 mediates oxidative burst in monocytes and has been shown to interact with a number of proteins including IL-4, CD20, CD2, CD9, IL-2, VLA-4, and CD4. Cross-linking of CD53 on monocytes induces a strong increase in intracellular calcium ions, whereas a modest increase is seen in B lymphocytes. In resting B cells, the molecule transmits a co-stimulatory signal and promotes activation through the Ig receptor.
Additional information: Clone REA259 displays negligible binding to Fc receptors.

Alternative names

MOX44, TSPAN25

Technical specifications

  • Antigen: CD53
  • Clone: REA259
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: MOX44, TSPAN25
  • Distribution of antigen: B cells, T cells, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Olweus, J. et al. (1993) CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells. J. Immunol. 151: 707-716
    2. Maecker, H. T, et al. (1997) The tetraspanin superfamily: molecular facilitators. FASEB J. 11: 428-442
    3. Angelisova, P. et al. (1990) The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens. Immunogenetics 32(4): 281-285
Product options: 12
130-101-798

CD53-FITC, human

for 30
tests
(1)
JPY 20,000
130-101-808

CD53-FITC, human

for 100
tests
(1)
JPY 49,000
130-101-799

CD53-PE, human

for 30
tests
(1)
JPY 24,000
130-101-782

CD53-PE, human

for 100
tests
(1)
JPY 57,000
130-101-795

CD53-APC, human

for 30
tests
(1)
JPY 24,000
130-101-780

CD53-APC, human

for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000
for 30
tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000

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