CD49e antibodies, mouse

CD49e antibodies, mouse

Clone: 5H10-27 | Dilution: 1:10
The monoclonal antibody 5H10-27 recognizes mouse CD49e, also known as integrin α5, which interacts with integrin β1 (CD29) to form the heterodimer VLA-5, the fibronectin receptor. It is expressed on activated T cells, thymocytes, mast cells, and splenic B cells and plays a role in cell-surface mediated signaling and in adhesion. The 5H10-27 antibody has been shown to inhibit VLA-5 mediated functions and promote the stimulation of CD8
+
cells
in vitro
.

Alternative names

ITGA5, FNRA, VLA5

Technical specifications

  • Antigen: CD49e
  • Clone: 5H10-27
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: ITGA5, FNRA, VLA5
  • Entrez Gene ID: 16402
  • Molecular mass of antigen [kDa]: 110
  • Distribution of antigen: T cells, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Rich, S. et al. (1996)
      Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8
      +
      T cell growth and apoptosis.
      J. Immunol. 157: 2916-2923
    2. Noto, K. et al. (1995) Identification and functional characterization of mouse CD29 with a mAb. Int. Immunol. 7: 835-842
    3. Hemler, M. E. et al. (1990) LA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu. Rev. Immunol. 8: 365-400
    4. Yang, J. T. et al. (1996) Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins. Mol. Biol. Cell 7: 1737-1748
Product options: 10
9 µg in 300 µL (1)
JPY 5,900
30 µg in 1 mL (1)
JPY 18,000
130-103-382

CD49e-PE, mouse

9 µg in 300 µL (1)
JPY 4,800
130-102-743

CD49e-PE, mouse

30 µg in 1 mL (1)
JPY 12,000
130-103-383

CD49e-APC, mouse

9 µg in 300 µL (1)
JPY 7,000
130-102-744

CD49e-APC, mouse

30 µg in 1 mL (1)
JPY 12,000
9 µg in 300 µL (1)
JPY 8,500
30 µg in 1 mL (1)
JPY 18,000
9 µg in 300 µL (1)
JPY 2,800
30 µg in 1 mL (1)
JPY 7,500

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