CD48 antibodies, human

CD48 antibodies, human

Clone: REA426 | Dilution: 1:50
Clone REA426 recognizes the human CD48 antigen, a glycosyl-phosphatidyl-inositol (GPI)-anchored cell-surface protein of the CD2 family of molecules, which is also known as B-lymphocyte activation marker BLAST-1, BCM1, MEM-102, or SLAM family member 2 (SLAMF2). CD48 is expressed on various hematopoietic cells and its expression is regulated by viral and bacterial products and immune-associated proteins. CD48 binds CD2 and other molecules, yet its high-affinity ligand in both mouse and human systems is CD244 (2B4). Despite its lack of an intracellular domain, stimulation of CD48 induces rearrangement of signaling factors in lipid rafts, Lck-kinase activity, and tyrosine phosphorylation. As an adhesion and co-stimulatory molecule, CD48 induces numerous effects in B and T lymphocytes, natural killer cells, mast cells, and eosinophils. Some of these depend upon cell-cell interactions via CD244-CD48 binding.
Additional information: Clone REA426 displays negligible binding to Fc receptors.

Alternative names

Blast-1, BCM1, BLAST, MEM-102, SLAMF2, hCD48, mCD48, TCT.1

Technical specifications

  • Antigen: CD48
  • Clone: REA426
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Blast-1, BCM1, BLAST, MEM-102, SLAMF2, hCD48, mCD48, TCT.1
  • Entrez Gene ID: 962
  • Molecular mass of antigen [kDa]: 22
  • Distribution of antigen: leukocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBlue
  • Selected references

    1. Tarakhovsky, A. et al. (1995) A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269(5223): 535-537
    2. Efanov, A. et al. (2010)
      CD5
      +
      CD23
      +
      leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation.
      Leukemia 24(5): 970-975
    3. Lundy, S. K. et al. (2014)
      Characterization and activity of Fas ligand producing CD5
      +
      B cells.
      Methods Mol. Biol. 1190: 81-102
Product options: 2
for 30
tests
(1)
-
for 100
tests
(1)
-

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