CD344 (Frizzled-4) antibodies, human

CD344 (Frizzled-4) antibodies, human

Clone: REA1096 | Dilution: 1:50
Clone REA1096 recognizes an extracellular epitope of the human CD344 antigen, a multi-pass membrane protein which is also known as Frizzled family receptor 4 (FZD4) or Frizzled-4. CD344 is expressed by neuronal stem cells and also found on fetal neuronal progenitor cells and neuronal intestinal cells. It is a member of the Frizzled family of proteins which encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. CD344 is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). It is the only representative of frizzled family members that binds strongly an additional ligand Norrin that is functionally similar but structurally different from Wingless type proteins. CD344 signaling induced by Norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear.
Additional information: Clone REA1096 displays negligible binding to Fc receptors.

Alternative names

Fz-4, hFz4, FzE4, FZD4, Fz4, GPCR

Technical specifications

  • Antigen: CD344 (Frizzled-4)
  • Clone: REA1096
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Fz-4, hFz4, FzE4, FZD4, Fz4, GPCR
  • Entrez Gene ID: 8322
  • Molecular mass of antigen [kDa]: 56
  • Distribution of antigen: fetal neuronal progenitor cells, neuronal intestinal cells, neural stem cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Kirikoshi, H. et al. (1999) Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21. Biochem. Biophys. Res. Commun. 264(3): 955-961
    2. Ye, X. et al. (2009) Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell 139(2): 285-298
    3. Descamps, B. et al. (2012) Frizzled 4 regulates arterial network organization through noncanonical Wnt/planar cell polarity signaling. Circ. Res. 110(1): 47-58
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