CD334 (FGFR4) antibodies, human

CD334 (FGFR4) antibodies, human

Clone: 4FR6D3 | Dilution: 1:11
Clone 4FR6D3 recognizes the human CD334 antigen, known as fibroblast growth factor receptor 4 (FGFR4) which is a member of the fibroblast growth factor receptor family. This cell surface tyrosine kinase is a high affinity receptor for both acidic and basic fibroblast growth factor. The binding of CD334 with the acidic fibroblast growth factors FGF2, FGF6, and FGF8, FGF19, and GFG1 induces mitogenesis and differentiation. CD334 is expressed in adrenal, lung, kidney, liver, pancreas, intestine, striated muscle, and spleen tissues of human fetuses. A soluble-form splice variant of FGFR 4 was identified in human gastrointestinal epithelial cells and cancer cells.

Alternative names

FGFR-4, FGFR4, TKF, FGF R4

Technical specifications

  • Antigen: CD334 (FGFR4)
  • Clone: 4FR6D3
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: FGFR-4, FGFR4, TKF, FGF R4
  • Entrez Gene ID: 2264
  • Molecular mass of antigen [kDa]: 86
  • Distribution of antigen: lung cancer cells, kidney, liver, pancreatic carcinoma cells, spleen
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio770, APC-Vio770
  • Selected references

    1. Partanan, J. et al. (1991) FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J. 10(6): 1347-1354
    2. Ron, D. et al. (1993) Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor. J. Biol. Chem. 268(8): 5388-5394
    3. Takaishi, S. et al. (2000) Identification of a novel alternative splicing of human FGF receptor 4: soluble-form splice variant expressed in human gastrointestinal epithelial cells. Biochem. Biophys. Res. Commun. 267(2): 658-662
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