CD326 (EpCAM) antibodies, human

CD326 (EpCAM) antibodies, human

Clone: REA764 | Dilution: 1:50
Clone REA764 recognizes CD326, also known as human epithelial antigen (HEA), epithelial cell adhesion molecule (EpCAM), or epithelial-specific antigen (ESA), and is involved in cell adhesion. The CD326 antigen is broadly expressed on the basolateral surface of carcinoma and epithelial cells in tissues or on circulating tumor cells and cancer stem cells, but is not found on melanoma, neuroblastoma, sarcoma, lymphoma, leukemia cells, or normal fibroblasts. Furthermore, it is suggested, that CD326 could be used as a surface marker for human ESCs.
Additional information: Clone REA764 displays negligible binding to Fc receptors.

Alternative names

EGP40, Ep-CAM, KSA, TROP1, MK-1

Technical specifications

  • Antigen: CD326 (EpCAM)
  • Clone: REA764
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: EGP40, Ep-CAM, KSA, TROP1, MK-1
  • Entrez Gene ID: 4072
  • Molecular mass of antigen [kDa]: 33
  • Distribution of antigen: cancer stem cells, epithelial cells, lung, ES and iPS cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Moldenhauer, G. et al. (1987) Epithelium specific surface glycoprotein of Mr 34,000 is a widely distributed human carcinoma marker. Br. J. Cancer 56: 714-721
    2. Sheridan, C. et al. (2006)
      CD44
      +
      /CD24
      -
      breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis.
      Breast Cancer Res. 8(5): R59
    3. Metsuyanim, S. et al. (2009) Expression of stem cell markers in the human fetal kidney. PLoS One 4(68): e6709
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