CD301 (CLEC10A) antibodies, mouse

CD301 (CLEC10A) antibodies, mouse

Clone: REA687 | Dilution: 1:10
Clone REA687 recognizes the mouse CD301 (CLEC10A) antigen, which is a 40 kDa type II transmembrane glycoprotein expressed by immature DCs and activated macrophages. Mouse CD301 has two homologue genes, CD301a (MGL1) and CD301b (MGL2). CD301 is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily which plays a role in cell adhesion, cell-cell signaling, glycoprotein turnover, inflammation, and immune response. CD301 binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine.
Additional information: Clone REA687 displays negligible binding to Fc receptors.

Alternative names

Clec10a, MGL, M-ASGP-BP-1

Technical specifications

  • Antigen: CD301 (CLEC10A)
  • Clone: REA687
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Clec10a, MGL, M-ASGP-BP-1
  • Entrez Gene ID: 17312
  • Molecular mass of antigen [kDa]: 35
  • Distribution of antigen: macrophages, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Tsuiji, M. et al. (2002) Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1. J. Biol. Chem. 277(32): 28892-28901
    2. Singh, S. K. et al. (2009) Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties. Mol. Immunol. 46(6): 1240-1249
    3. Denda-Nagai, K. et al. (2010) Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells. J. Biol. Chem. 285(25): 19193-19204
Product options: 10
9 µg in 300 µL (1)
JPY 6,800
30 µg in 1 mL (1)
JPY 18,000
9 µg in 300 µL (1)
JPY 4,800
30 µg in 1 mL (1)
JPY 12,000
9 µg in 300 µL (1)
JPY 7,000
30 µg in 1 mL (1)
JPY 12,000
9 µg in 300 µL (1)
JPY 8,500
30 µg in 1 mL (1)
JPY 18,000
9 µg in 300 µL (1)
JPY 2,800
30 µg in 1 mL (1)
JPY 7,500