CD294 (CRTH2) antibodies, human

CD294 (CRTH2) antibodies, human

Clone: REA598 | Dilution: 1:50
Clone REA598 recognizes the CD294 antigen, also known as chemoattractant receptor-homologous molecule expressed on Tʜ2 cells (CRTH2). CD294 is a seven-transmembrane G protein–coupled receptor for prostaglandin D2 involved in migration of leukocytes and is expressed on T helper type 2 (Tʜ2) cells, a subpopulation of CD4
+
T cells, but not on Tʜ1 cells. The CD294 antigen is highly expressed on peripheral blood basophils and eosinophils. It is also present on a small population of CD8
+
T cells and on a subpopulation of dendritic cells (DCs).
Additional information: Clone REA598 displays negligible binding to Fc receptors.

Alternative names

CRTH2

Technical specifications

  • Antigen: CD294 (CRTH2)
  • Clone: REA598
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CRTH2
  • Entrez Gene ID: 11251
  • Molecular mass of antigen [kDa]: 43
  • Distribution of antigen: T helper cells, basophils, eosinophils, T cells, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Nagata, K. et al. (1999)
      Selective expression of a novel surface molecule by human Tʜ2 cells
      in vivo
      .
      J. Immunol. 162: 1278-1286
    2. Messi, M. et al. (2003) Memory and flexibility of cytokine gene expression as separable properties of human Tʜ1 and Tʜ2 lymphocytes. Nat. Immunol. 4: 78-86
    3. Nagata, K. et al. (1999) CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett. 459: 195-199
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