CD294 (CRTH2) antibodies, human

CD294 (CRTH2) antibodies, human

Clone: BM16 | Dilution: 1:50
Clone BM16 recognizes the CD294 antigen, also known as chemoattractant receptor-homologous molecule expressed on Tʜ2 cells (CRTH2). CD294 is a seven-transmembrane G protein-coupled receptor for prostaglandin D
2
involved in migration of leukocytes and is expressed on T helper type 2 (Tʜ2) cells, a subpopulation of CD4
+
T cells, but not on Tʜ1 cells. The CD294 antigen is highly expressed on peripheral blood basophils and eosinophils. It is also present on a small population of CD8
+
T cells and on a subpopulation of dendritic cells.

Alternative names

PTGDR2, CRTH2, DL1R, DP2, GPR44

Technical specifications

  • Antigen: CD294 (CRTH2)
  • Clone: BM16
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: PTGDR2, CRTH2, DL1R, DP2, GPR44
  • Entrez Gene ID: 11251
  • Molecular mass of antigen [kDa]: 43
  • Distribution of antigen: basophils, brain, eosinophils, gut, heart, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, Biotin
  • Selected references

    1. Nagata, K. et al. (1999)
      Selective expression of a novel surface molecule by human Tʜ2 cells
      in vivo
      .
      J. Immunol. 162: 1278-1286
    2. Messi, M. et al. (2003) Memory and flexibility of cytokine gene expression as separable properties of human Tʜ1 and Tʜ2 lymphocytes. Nat. Immunol. 4: 78-86
    3. Cosmi, L. et al. (2000) CRTH2 is the most reliable marker for the detection of circulating human type 2 Tʜ and type 2 T cytotoxic cells in health and disease. Eur. J. Immunol. 30: 2972-2979
    4. Nagata, K. et al. (1999) CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett. 459: 195-199
Product options: 4
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000

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