CD286 (TLR6) antibodies, human

CD286 (TLR6) antibodies, human

Clone: REA382 | Dilution: 1:11
Clone REA382 recognizes the human CD286 antigen, a single-pass type I membrane protein also known as toll-like receptor 6 (TLR6). CD286 is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. Toll-like receptors are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various toll-like receptors exhibit different patterns of expression. CD286 is colocalized with TLR2 on the cell surface of monocytes/macrophages, dendritic cells, and granulocytes. It participates in the innate immune response to gram-positive bacteria and fungi and specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. CD286 acts via MYD88 and TRAF6, leading to NFκB activation, cytokine secretio,n and the inflammatory response.
Additional information: Clone REA382 displays negligible binding to Fc receptors.

Alternative names

TLR6

Technical specifications

  • Antigen: CD286 (TLR6)
  • Clone: REA382
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TLR6
  • Entrez Gene ID: 10333
  • Molecular mass of antigen [kDa]: 88
  • Distribution of antigen: monocytes, macrophages, dendritic cells, granulocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Takeuchi, O. et al. (1999) TLR6: A novel member of an expanding toll-like receptor family. Gene 231(1-2): 59-65
    2. Buwitt-Beckmann, U. et al. (2006) TLR1- and TLR6-independent recognition of bacterial lipopeptides. J. Biol. Chem. 281(14): 9049-9057
    3. Jin B. et al. (2012) The effects of TLR activation on T-cell development and differentiation. Clin. Dev. Immunol. 2012(836485): doi: 10.1155/2012/83
Product options: 8
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