CD223 antibodies, mouse

CD223 antibodies, mouse

Clone: REA776 | Dilution: 1:50
Clone REA776 recognizes an epitope within the D2 domain of murine CD233, also known as LAG-3, which is a 70 kDa high affinity MHC class II ligand. It is expressed on activated CD4
+
and CD8
+
α/β T cells, on a subset of NK cells, B cells and plasmacytoid dendritic cells. It is proposed, that LAG-3 could be used as a marker of T cell induced B cell activation.
In association with the CD3 complex CD223 is a negative regulatory molecule to inhibit TCR-mediated signaling and to regulate homeostatic T cell expansion.
Additional information: Clone REA776 displays negligible binding to Fc receptors

Alternative names

LAG-3, Ly66

Technical specifications

  • Antigen: CD223
  • Clone: REA776
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: LAG-3, Ly66
  • Entrez Gene ID: 16768
  • Molecular mass of antigen [kDa]: 55
  • Distribution of antigen: NK cells, T cells, B cells, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBright 515, Biotin
  • Selected references

    1. Baixeras, E. et al. (1992) Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. J. Exp. Med. 176(2): 327-337
    2. Workman, C. J. et al. (2002) Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur. J. Immunol. 32(8): 2255-2263
    3. Workman, C. J. et al. (2002) Cutting edge: Molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J. Immunol. 169(10): 5392-5395
    4. Kisielow, M. et al. (2005) Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells. Eur. J. Immunol. 35(7): 2081-2088
Product options: 8
130-111-513

CD223-PE, mouse

30 µg in 200 µL (1)
JPY 12,000
130-111-327

CD223-PE, mouse

150 µg in 1 mL (1)
JPY 35,000
130-111-514

CD223-APC, mouse

30 µg in 200 µL (1)
JPY 12,000
130-111-328

CD223-APC, mouse

150 µg in 1 mL (1)
JPY 35,000
30 µg in 200 µL (1)
JPY 25,000
150 µg in 1 mL (1)
JPY 73,000
30 µg in 200 µL (1)
JPY 7,500
150 µg in 1 mL (1)
JPY 22,000

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