CD223 antibodies – functional grade, mouse

CD223 antibodies – functional grade, mouse

Clone: C9B7W
Clone C9B7W recognizes an epitope within the D2 domain of murine CD233, also known as LAG-3, which is a 70 kDa high affinity MHC class II ligand. It is expressed on activated CD4
+
and CD8
+
α/β T cells and on a subset of NK cells. It has been reported that in association with the CD3 complex CD223 is a negative regulatory molecule to inhibit TCR-mediated signaling and to regulate homeostatic T cell expansion.

Applications

This pure – functional grade antibody is suited for cell culture functional assays, for example, blocking of receptor-ligand binding.

Alternative names

LAG-3, Ly66

Technical specifications

  • Antigen: CD223
  • Clone: C9B7W
  • Isotype: rat IgG1
  • Alternative names of antigen: LAG-3, Ly66
  • Entrez Gene ID: 16768
  • Molecular mass of antigen [kDa]: 55
  • Distribution of antigen: NK cells, T cells
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Workman, C. J. et al. (2002) Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur. J. Immunol. 32(8): 2255-2263
    2. Workman, C. J. et al. (2002) Cutting edge: Molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J. Immunol. 169(10): 5392-5395
    3. Baixeras, E. et al. (1992) Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. J. Exp. Med. 176(2): 327-337
Product options: 1
500 µg in 0.5 mL
JPY 68,000

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