CD220 antibodies, human

CD220 antibodies, human

Clone: REA260 | Dilution: 1:11
Clone REA260 recognizes the CD220 antigen, a type I transmembrane receptor tyrosine kinase, which is also known as insulin receptor (IR). CD220 is predominantly expressed in major target tissues of insulin metabolic effects like liver, adipose tissue, and skeletal muscle, but is also expressed in the peripheral nerve, kidney, fibroblasts, monocytes, granulocytes, erythrocytes, and skin. It is composed of two extracellular α-subunits and two transmembrane β-subunits. Upon binding of insulin, CD220 forms a heterotetramer of two units to induce autophosphorylation and activation of the tyrosine kinase activity of the receptor. CD220 plays a key role in the regulation of glucose homeostasis, cell growth, differentiation, and apoptosis- functional processes that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer.
Additional information: Clone REA260 displays negligible binding to Fc receptors.

Alternative names

INSR, HHF5

Technical specifications

  • Antigen: CD220
  • Clone: REA260
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: INSR, HHF5
  • Entrez Gene ID: 3643
  • Molecular mass of antigen [kDa]: 307
  • Distribution of antigen: monocytes, fibroblasts, red blood cells, granulocytes, liver
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Youngren, J. F. et al. (2007) Regulation of insulin receptor function. Cell. Mol. Life Sci. 64(7-8): 873-891
    2. Czech, M. P. et al. (1985) The nature and regulation of the insulin receptor: structure and function. Annu. Rev. Physiol. 47: 357-381
    3. Chiu, S. L. et al. (2010) Insulin receptor signaling in the development of neuronal structure and function. Neural Dev. 5: 7
Product options: 8
130-103-717

CD220-PE, human

for 30
tests
(1)
JPY 24,000
130-103-652

CD220-PE, human

for 100
tests
(1)
JPY 57,000
130-103-718

CD220-APC, human

for 30
tests
(1)
JPY 24,000
130-103-653

CD220-APC, human

for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000

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