CD182 (CXCR2) antibodies, human

CD182 (CXCR2) antibodies, human

Clone: REA208 | Dilution: 1:11
Clone REA208 recognizes CD182 (CXCR2), which belongs to the class of chemokine receptors specific for CXC chemokines. Chemokine receptors are G-coupled protein receptors (GPCR) with seven-transmembrane domains and consist of an α-subunit and a βγ-complex. In humans, interleukin 8 (IL-8) is one of most potent chemokine which binds to CXCR2. Expression of CD182 is found on several cell types including leukocytes, endothelial, and epithelial cells. CD182 plays a critical role in neutrophil homeostatis, angiogenesis, and in pathological conditions such as acute lung injury, lung diseases, and asthma.
Additional information: Clone REA208 displays negligible binding to Fc receptors.

Alternative names

CXCR2, CDw128b, CMKAR2, IL8R2, IL8RA, CD128b, IL-8RB

Technical specifications

  • Antigen: CD182 (CXCR2)
  • Clone: REA208
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CXCR2, CDw128b, CMKAR2, IL8R2, IL8RA, CD128b, IL-8RB
  • Distribution of antigen: leukocytes, endothelial cells, epithelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Belperio, J. A. et al. (2005) CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury. J. Immunol. 175: 6931-6939
    2. Thatcher, T. H. et al. (2005) Role of CXCR2 in cigarette smoke-induced lung inflammation. Am. J. Physiol. Lung Cell Mol. Physiol. 289: L322-L328
Product options: 8
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JPY 24,000
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JPY 57,000
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JPY 24,000
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JPY 57,000
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JPY 25,000
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JPY 59,000
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JPY 20,000
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JPY 49,000