CD180 (RP105) antibodies, human

CD180 (RP105) antibodies, human

Clone: REA956 | Dilution: 1:50
Clone REA956 recognizes the human CD180 antigen, also known as RP105, which is a 105 kDa type 1 transmembrane protein of the toll-like receptor (TLR) family. The extracellular domain of CD180 is associated with MD-1, which forms the cell surface complex RP105/MD-1. Together with TLR4, it mediates B cell recognition and signaling of LPS. RP105 is expressed on mature B cells in mantle zones as well as on monocytes, macrophages, and dendritic cells.
Additional information: Clone REA956 displays negligible binding to Fc receptors.

Alternative names

LY64, Ly78, RP105

Technical specifications

  • Antigen: CD180 (RP105)
  • Clone: REA956
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LY64, Ly78, RP105
  • Entrez Gene ID: 4064
  • Molecular mass of antigen [kDa]: 72
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    olive baboon (
    Papio anubis
    )
  • Distribution of antigen: dendritic cells, macrophages, monocytes, plasma cells, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Miura, Y. et al. (1998) RP105 Is associated with MD-1 and transmits an activation signal in human B cells. Blood 92: 2815-2822
    2. Ogata, H. et al. (2000) The toll-like receptor protein Rp105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med. 192: 23-30
    3. Divanovic, S. et al. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat. Immunol. 6(6): 571-578
Product options: 14
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(1)
JPY 24,000
for 100
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JPY 57,000
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JPY 24,000
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JPY 57,000
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JPY 25,000
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JPY 59,000
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JPY 25,000
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(1)
JPY 59,000
for 30
tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000
for 30
tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000
for 30
tests
(1)
JPY 20,000
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JPY 49,000