CD18 antibodies, mouse

CD18 antibodies, mouse

Clone: REA1226 | Dilution: 1:50
Clone REA1226 recognizes the murine CD18 antigen, a 95 kDa glycoprotein also known as integrin beta-2 (ITGB2). CD18 associates non-covalently with CD11a, CD11b, and CD11c to form LFA-1, Mac-1, and gp150/95, respectively and plays an important role in leukocytes adhesion. It is expressed on all leukocytes with NK and T cells showing higher density of surface expression. The CD18 integrin complexes bind CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), iC3b, and fibrinogen. Heterodimers of CD18 with α subunits show different expression patterns on different leucocytes. Mice leucocytes lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.
Additional information: Clone REA1226 displays negligible binding to Fc receptors.

Alternative names

Integrin beta-2, ITGB2, LTbetaR, TNF-R-III, Ltbr, TNFR-RP, TNFR2-RP, TNFCR, Tnfbr

Technical specifications

  • Antigen: CD18
  • Clone: REA1226
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Integrin beta-2, ITGB2, LTbetaR, TNF-R-III, Ltbr, TNFR-RP, TNFR2-RP, TNFCR, Tnfbr
  • Entrez Gene ID: 17000
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: leukocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio615, PE-Vio770, Biotin, PE
  • Selected references

    1. Wilson, R. W. et al. (1993) Gene targeting yields a CD18-mutant mouse for study of inflammation. J. Immunol. 151: 1571-1578
    2. Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32(3): 241-269
    3. Jakus, Z. et al. (2007) Immunoreceptor-like signaling by β 2 and β 3 integrins. Trends Cell Biol. 17(10): 493-501
Product options: 5
130-124-119

CD18-PE, mouse

30 µg in 200 µL (1)
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130-124-120

CD18-APC, mouse

30 µg in 200 µL (1)
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30 µg in 200 µL (1)
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30 µg in 200 µL (1)
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30 µg in 200 µL (1)
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