CD170 (Siglec-5) antibodies, human

CD170 (Siglec-5) antibodies, human

Clone: 1A5 | Dilution: 1:11
Clone 1A5 recognizes the CD170 antigen, a single-pass transmembrane protein member of the immunoglobulin superfamily, also known as sialic acid-binding Ig-like lectin 5 (siglec-5). CD170 is expressed on neutrophils, monocytes, dendritic cells, and subsets of tissue macrophages. It contains two tyrosine-based motifs in its cytoplasmic tail implicating signaling functions and forms a 140 kDa dimer on the cell surface. Tyrosine phosphorylation of CD170 leads to recruitment of the tyrosine phosphatases SHP-1 and SHP-2, which in turn efficiently inhibits FcεRI-mediated calcium fluxing and serotonin release. CD170 binds α 2-3– and α 2-6–linked sialic acid as well as glycophorin A, and is involved in cell adhesion.

Alternative names

CD33L2, OB-BP2, OBBP2, Siglec-5

Technical specifications

  • Antigen: CD170 (Siglec-5)
  • Clone: 1A5
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CD33L2, OB-BP2, OBBP2, Siglec-5
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
    ,
    bonobo (
    Pan paniscus
    )
  • Distribution of antigen: macrophages, monocytes, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Erickson-Miller, C. L. et al. (2003) Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. Exp. Hematol. 31(5): 382-388
    2. Cornish, A. L. et al. (1998) Characterization of Siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. Blood 92(6): 2123-2132
    3. Avril, T. et al. (2005) Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J. Biol. Chem. 280: 19843-19851
Product options: 12
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JPY 59,000
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tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000

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