CD159a (NKG2A) antibodies, mouse

CD159a (NKG2A) antibodies, mouse

Clone: REA1161 | Dilution: 1:50
Clone REA1161 recognizes the CD159a (NKG2A) antigen, an inhibitory natural killer (NK) cell receptor. CD159a forms heterodimer with CD94 and contains a C-type lectin ectodomain. Inhibitory signal is transmitted by the heterodimer via immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and upon ligand engagement, ITIMs are phosphorylated and transmit signal through docking of various tyrosine phosphatases. CD159a/CD94 binds non-classical MHC class I protein, HLA-E. Expression of CD159a is found mainly on NK cells, NKT cells, and on subsets of CD8
+
cells.
Additional information: Clone REA1161 displays negligible binding to Fc receptors.

Alternative names

KLRC1, NKG2A

Technical specifications

  • Antigen: CD159a (NKG2A)
  • Clone: REA1161
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: KLRC1, NKG2A
  • Entrez Gene ID: 16641
  • Molecular mass of antigen [kDa]: 28
  • Distribution of antigen: NK cells, NKT cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected references

    1. Vance, R. E. et al. (1998) Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J. Exp. Med. 188(10): 1841-1848
    2. Vance, R. E. et al. (2002) Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. Proc. Natl. Acad. Sci. U.S.A. 99(2): 868-873
    3. Rapaport, A. S. et al. (2015)
      The inhibitory receptor NKG2A sustains virus-specific CD8
      +
      T cells in response to a lethal poxvirus infection.
      Immunity 43(6): 1112-1124
Product options: 6
30 µg in 200 µL (1)
JPY 12,000
150 µg in 1 mL (1)
JPY 35,000
30 µg in 200 µL (1)
JPY 12,000
150 µg in 1 mL (1)
JPY 35,000
30 µg in 200 µL (1)
JPY 18,000
150 µg in 1 mL (1)
JPY 52,000