Clone REA238 recognizes the human CD154 antigen, a 39 kDa transmembrane glycoprotein, also known as CD40L, gp39, T-BAM, TRAP, or Ly-62, which is a proinflammatory and prothrombotic ligand in the tumor necrosis factor family. CD154 is transiently up-regulated on activated CD4
+
T cells and plays an important role as a costimulatory molecule in T cell/antigen-presenting cell interactions through ligation of CD40. It mediates B cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4.
Additional information: Clone REA238 displays negligible binding to Fc receptors.

Alternative names

CD40L, CD40-L, gp39, T-BAM, TRAP, Ly-62, HIGM1, IGM

Technical specifications

  • Antigen: CD154
  • Clone: REA238
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD40L, CD40-L, gp39, T-BAM, TRAP, Ly-62, HIGM1, IGM
  • Entrez Gene ID: 959
  • Molecular mass of antigen [kDa]: 29
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: basophils, dendritic cells, lymphocytes, macrophages, mast cells, monocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, PerCP-Vio700, Biotin, VioBright 515, PE-Vio615
  • Selected references

    1. Hollenbaugh, D. et al. (1992) The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO J. 11(12): 4313-4321
    2. Frentsch, M. et al. (2005)
      Direct access to CD4
      +
      T cells specific for defined antigens according to CD154 expression.
      Nat. Med. 11: 1118-1124
    3. Furman, M. et al. (2004) Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization. J. Am. Coll. Cardiol. 43(12): 2319-2325
Product options: 18
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000
130-114-139

CD154-PE, human

for 30
tests
(1)
JPY 24,000
130-113-613

CD154-PE, human

for 100
tests
(1)
JPY 57,000
130-114-136

CD154-APC, human

for 30
tests
(1)
JPY 24,000
130-113-610

CD154-APC, human

for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 58,000
for 30
tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000
for 30
tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000
for 30
tests
(1)
JPY 31,000
for 100
tests
(1)
JPY 75,000
for 30
tests
(1)
-
for 100
tests
(1)
-

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