CD144 (VE-Cadherin) antibodies, mouse

CD144 (VE-Cadherin) antibodies, mouse

Clone: REA225 | Dilution: 1:10
Clone REA225 recognizes mouse CD144, which is also known as cadherin 5 or vascular endothelial cadherin (VE-Cadherin). This calcium-dependent cell–cell adhesion glycoprotein is composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. CD144 is a strictly endothelial specific adhesion molecule located at junctions between endothelial cells and is of vital importance for the maintenance and control of endothelial cell contacts. Mechanisms that regulate VE-cadherin–mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. CD144 also regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions.
Additional information: Clone REA225 displays negligible binding to Fc receptors.

Alternative names

CDH5, 7B4, VE-Cad, VECD, VEcad, Vec

Technical specifications

  • Antigen: CD144 (VE-Cadherin)
  • Clone: REA225
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CDH5, 7B4, VE-Cad, VECD, VEcad, Vec
  • Entrez Gene ID: 12562
  • Molecular mass of antigen [kDa]: 83
  • Distribution of antigen: endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Biotin, PE, APC
  • Selected references

    1. Vestweber, D. et al. (2008) VE-Cadherin: The major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler. Thromb. Vasc. Biol. 28: 223-232
    2. Lampugnani, M. G. et al. (1992) A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J. Cell Biol. 118: 1511
    3. Ali, J. et al. (1997) Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. MIcrocirculation 4(2): 267-277
Product options: 6
9 µg in 300 µL (1)
JPY 4,800
30 µg in 1 mL (1)
JPY 12,000
9 µg in 300 µL (1)
JPY 7,000
30 µg in 1 mL (1)
JPY 12,000
9 µg in 300 µL (1)
JPY 2,800
30 µg in 1 mL (1)
JPY 7,500

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