CD142 antibodies, human

CD142 antibodies, human

Clone: REA949 | Dilution: 1:50
Clone REA949 recognizes the human CD142 antigen, a 45 kDa type I transmembrane glycoprotein also known as tissue factor (TF). It functions as the high-affinity receptor for the coagulation factor VII and enables cells to initiate the blood coagulation cascades. It is reported, that the tissue factor exists in a membrane-bound and in a soluble form. It is expressed on activated endothelial cells and on monocytes, macrophages, and platelets, which are stimulated with inflammatory mediators such as LPS or tumor necrosis factor alpha (TNFα). CD142 is also present on some tumor cells such as lung, breast, pancreatic, and colon, as well as on non-immune-tissues.
Additional information: Clone REA949 displays negligible binding to Fc receptors

Alternative names

Tissue Factor, Coagulation factor III, Thromboplastin, TF

Technical specifications

  • Antigen: CD142
  • Clone: REA949
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Tissue Factor, Coagulation factor III, Thromboplastin, TF
  • Entrez Gene ID: 2152
  • Molecular mass of antigen [kDa]: 30
  • Distribution of antigen: endothelial cells, macrophages, monocytes, platelets, tumor cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, Biotin
  • Selected references

    1. Carson, S. D. et al. (1994) Fibroblast tissue factor: calcium and ionophore induce shape changes, release of membrane vesicles, and redistribution of tissue factor antigen in addition to increased procoagulant activity. Blood 84: 526-534
    2. Golino, P. et al. (2002) The inhibitors of the tissue factor: factor VII pathway. Thromb. Res. 106(3): V257-V265
    3. Bogdanov, V. Y. et al. (2003) Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat. Med. 9: 458-462
    4. Butenas, S. et al. (2008) Tissue factor activity and function in blood coagulation. Thromb. Res. 122: S42-S46
Product options: 11
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000
130-115-712

CD142-PE, human

for 30
tests
(1)
JPY 24,000
130-115-684

CD142-PE, human

for 100
tests
(1)
JPY 57,000
130-115-713

CD142-APC, human

for 30
tests
(1)
JPY 24,000
130-115-685

CD142-APC, human

for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000
for 100
tests
(1)
JPY 59,000
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000

Related products

2 products available