CD114 antibodies, human

CD114 antibodies, human

Clone: LMM741 | Dilution: 1:11
Clone LMM741 binds the receptor for granulocyte colony stimulating factor (G-CSFR, CSF3), a 130–150 kDa type I transmembrane glycoprotein of the class 1 cytokine receptor gene family also known as CD114. Ligand binding leads to homodimerization and subsequent signal transduction involving the JAK-STAT pathway. CD114 is expressed by neutrophils at all stages of differentiation but also found on monocytes, endothelial cells, mature platelets, trophoblasts, and placenta.

Alternative names

CSF-3R, G-CSFR

Technical specifications

  • Antigen: CD114
  • Clone: LMM741
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CSF-3R, G-CSFR
  • Entrez Gene ID: 1441
  • Molecular mass of antigen [kDa]: 90
  • Distribution of antigen: endothelial cells, granulocytes, monocytes, neutrophils, placenta, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, Biotin, PE
  • Selected references

    1. Piper, M. G. et al. (2010) Neutrophil elastase downmodulates native GCSFR expression and granulocyte-macrophage colony formation. J. Inflamm. 7(1): 5
    2. Liongue, C. et al. (2009) Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more. Int. J. Biochem. Cell Biol. 12(41): 2372-2375
    3. Ward, A. C. (2007) The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease. Front Biosci. 12: 608-618
    4. Gibbs, K. D. et al. (2011) Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments. Blood (117): 4226-4233
Product options: 3
130-097-309

CD114-PE, human

for 100
tests
(1)
JPY 57,000
130-097-308

CD114-APC, human

for 100
tests
(1)
JPY 57,000
for 100
tests
(1)
JPY 49,000

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