CD110 antibodies, human

CD110 antibodies, human

Clone: REA250 | Dilution: 1:11
Clone REA250 recognizes the CD110 antigen, a type I transmembrane protein and a member of the hematopoietin receptor family, which is also known as myeloproliferative leukemia protein (MPL) or thrombopoietin receptor (TPO-R). CD110 is expressed on hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets. It serves as a receptor for thrombopoietin and CD110 deficiency leads to severe thrombocytopenia, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation.
Additional information: Clone REA250 displays negligible binding to Fc receptors.

Alternative names

MPL, C-MPL, MPLV, THCYT2, TPOR

Technical specifications

  • Antigen: CD110
  • Clone: REA250
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: MPL, C-MPL, MPLV, THCYT2, TPOR
  • Distribution of antigen: platelets, megakaryocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Vigon, I. et al. (1992) Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad. Sci. U.S.A. 89: 5640-5644
    2. Chou, F. S. et al. (2011) The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis. J. Cell. Biochem. 112(6): 1491-1498
    3. Kaushansky, K. et al. (1998) The role of the MPL receptor in myeloproliferative disorders. Leukemia 12: S47-S50
Product options: 8
130-101-648

CD110-PE, human

for 30
tests
(1)
JPY 24,000
130-101-743

CD110-PE, human

for 100
tests
(1)
JPY 57,000
130-101-647

CD110-APC, human

for 30
tests
(1)
JPY 24,000
130-101-644

CD110-APC, human

for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 25,000
for 100
tests
(1)
JPY 59,000
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000

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