Anti-TIGIT antibodies, human

Anti-TIGIT antibodies, human

Clone: REA1004 | Dilution: 1:50
Clone REA1004 recognizes the human T cell immunoglobulin and ITIM domain (TIGIT) antigen, a protein containing an immunoglobulin variable (IgV) domain, a transmembrane domain, and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on T cells, including Treg cells and memory subsets, as well as on natural killer (NK) cells. The poliovirus receptor (PVR; also called NECL5 or CD155) is a high-affinity coreceptor for TIGIT that is highly expressed on dendritic cells (DCs), fibroblasts, endothelial cells, and some tumor cells. The interaction of TIGIT with PVR on DCs leads to the down-regulation of pro-inflammatory cytokine secretion and the induction of interleukin 10 (IL-10) production in DCs, exerting an inhibitory effect on T cell activation.
Additional information: Clone REA1004 displays negligible binding to Fc receptors.

Alternative names

VSIG9, Vstm3, WUCAM

Technical specifications

  • Antigen: TIGIT
  • Clone: REA1004
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: VSIG9, Vstm3, WUCAM
  • Entrez Gene ID: 201633
  • Molecular mass of antigen [kDa]: 24
  • Distribution of antigen: dendritic cells, NK cells, T cells, tumor cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, VioBright 515, Biotin
  • Selected references

    1. Yu, X. et al. (2009) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat. Immunol. 10(1): 48-57
    2. Levin, S. D. et al. (2011) Vstm3 is a member of the CD28 family and an important modulator of T-cell function. Eur. J. Immunol. 41(4): 902-915
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