Anti-STAT5a antibodies, human

Anti-STAT5a antibodies, human

Clone: REA549 | Dilution: 1:11
Clone REA549 recognizes the human STAT5a antigen, a member of signal transducers and activators of the transcription (STAT) family. The seven STAT family members play a critical role in activation of signaling pathways in response to the presence of various cytokines and growth factors (interferon (IFN)-α, IFN-γ, EGF, PDGF, and interleukin (IL)-6). STAT5a regulates the expression of milk proteins during lactation and mediates cellular responses to the receptor tyrosine-protein kinase ERBB4. It may induce cellular responses to activated FGFR1, FGFR2, FGFR3, and FGFR4. Among others STAT5a is expressed in prostate and breast cancer.
Additional information: Clone REA549 displays negligible binding to Fc receptors.

Alternative names

MGF, STAT5

Technical specifications

  • Antigen: STAT5a
  • Clone: REA549
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: MGF, STAT5
  • Entrez Gene ID: 6776
  • Molecular mass of antigen [kDa]: 91
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Lin, J. X. et al. (2000) The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19(21): 2566-2576
    2. Aoki, N. et al. (2002) A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. Mol Endocrinol. 16(1): 58-69
    3. Williams, C. C. et al. (2004) The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J. Cell Biol. 167(3): 469-478
Product options: 6
for 30
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(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 57,000

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