Anti-STAT4 pY693 antibodies, human

Anti-STAT4 pY693 antibodies, human

Clone: REA855 | Dilution: 1:50
Clone REA855 recognizes the human signal transducer and activator of transcription 4 (STAT4) antigen phosphorylated at tyrosine 693 (pY693). STAT4 is a member of signal transducers and activators of the transcription (STAT) family. STAT proteins transmit signals from a receptor complex to the nucleus and activate gene expression. The seven STAT family members play a critical role in activation of signaling pathways in response to the presence of various cytokines and growth factors (interferon α (IFN-α), interferon γ (IFN-γ), EGF, PDGF, and interleukin 6 (IL-6)). STAT4 is involved in the development of Tʜ1 cells from naive CD4
+
T cells and IFN-γ production in response to IL-12.
Additional information: Clone REA855 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: STAT4 pY693
  • Clone: REA855
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Entrez Gene ID: 6775
  • Molecular mass of antigen [kDa]: 86
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Vio515
  • Selected references

    1. Yamamoto, K. et al. (1994) Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. Mol. Cell. Biol. 14(7): 4342-4349
    2. Bacon, C. M. et al. (1995) Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 92(16): 7307-7311
    3. Kaplan, M. H. (2005)
      STAT4: a critical regulator of inflammation
      in vivo
      .
      Immunol. Res. 31(3): 231-242
Product options: 8
for 30
tests
(1)
JPY 20,000
for 100
tests
(1)
JPY 49,000
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 58,000

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