Anti-SHIP-1 antibodies, human and mouse

Anti-SHIP-1 antibodies, human and mouse

Clone: REA580 | Dilution: 1:10
Clone REA580 recognizes the human and mouse SHIP-1 antigen, which is a 145 kDa protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. SHIP-1, also known as enzyme phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, is expressed on hematopoietic cells, including immature CD34
+
cells, the majority of T cells, and a minority of B cells. It has a negative effect on cell growth and therefore loss or modification may have profound effects on hematopoietic cell development. Thus SHIP-1 functions as a negative regulator of myeloid cell proliferation and survival.
Additional information: Clone REA580 displays negligible binding to Fc receptors.

Alternative names

INPP5D, SHIP, SIP-145, hp51CN, p150Ship, SHIP1

Technical specifications

  • Antigen: SHIP-1
  • Clone: REA580
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: INPP5D, SHIP, SIP-145, hp51CN, p150Ship, SHIP1
  • Entrez Gene ID: 3635, 16331
  • Molecular mass of antigen [kDa]: 133, 134
  • Distribution of antigen: hematopoietic cells, T cells, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Drayer, A. L. et al. (1996) Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Biochem. Biophys. Res. Commun. 225(1): 243-249
    2. Ware, M. D. et al. (1996) Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation. Blood 88(8): 2833-2840
    3. Geier, S. J. et al. (1997) The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood. Blood 89(6): 1876-1885
Product options: 4
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 57,000
for 30
tests
(1)
JPY 24,000
for 100
tests
(1)
JPY 57,000