Anti-Plexin-B2 antibodies, mouse

Anti-Plexin-B2 antibodies, mouse

Clone: REA445 | Dilution: 1:10
Clone REA445 recognizes the mouse Plexin-B2 antigen, a Single-pass type I membrane protein which belongs to the semaphorin receptor family, B subfamily. Plexin-B2 is expressed in the nervous system and on other cells including cells of the immune system. It is expressed on T cells and T-dependent germinal center B cells. Expression is also found on macrophages, conventional dendritic cells and plasmacytoid dendritic cells. Plexin-B2 plays an important role in cell-cell signaling, axon guidance, invasive growth and cell migration. It has several semaphorin ligands including Semaphorin-3E, Semaphorin-4A, Semaphorin-4C, and Semaphorin-4D (CD100). Binding to class 4 semaphorins promotes the downstream activation of RHOA and phosphorylation of ERBB2. During skin damage repairs, CD100 interacts with Plexin-B2 on gamma delta T cells to play a role in the healing process.
Additional information: Clone REA445 displays negligible binding to Fc receptors.

Alternative names

Plxnb2, Debt

Technical specifications

  • Antigen: Plexin-B2
  • Clone: REA445
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Plxnb2, Debt
  • Entrez Gene ID: 140570
  • Molecular mass of antigen [kDa]: 54
  • Distribution of antigen: B cells, T cells, macrophages, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Witherden, D.A. et al. (2012) The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function. Immunity 37(2): 314-325
    2. Deng, S. et al. (2007)
      Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system
      in vivo
      J. Neurosci. 27(23): 6333-6347
    3. Saha, B. et al. (2012) Plexin-B2 regulates the proliferation and migration of neuroblasts in the postnatal and adult subventricular Zone. J. Neurosci. 32(47): 16892-16905
Product options: 8
9 µg in 300 µL (1)
JPY 6,800
30 µg in 1 mL (1)
JPY 18,000
9 µg in 300 µL (1)
JPY 4,800
30 µg in 1 mL (1)
JPY 12,000
9 µg in 300 µL (1)
JPY 7,000
30 µg in 1 mL (1)
JPY 12,000
9 µg in 300 µL (1)
JPY 2,800
30 µg in 1 mL (1)
JPY 7,500

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