Anti-PEAR1 antibodies, human

Anti-PEAR1 antibodies, human

Clone: REA790 | Dilution: 1:50
Clone REA790 recognizes the human platelet endothelial aggregation receptor 1 (PEAR1) antigen, a type I transmembrane protein also known as MEGF12. PEAR1, an EGF-containing receptor and member of the MEGF family, is found in various tissues. High levels of PEAR1 are found in platelets and endothelial cells, it is weakly expressed in peripheral blood leukocytes and macrophages. PEAR1 becomes activated by platelet contact and is involved in agonist-induced platelet aggregation.
Additional information: Clone REA790 displays negligible binding to Fc receptors.

Alternative names

MEGF12

Technical specifications

  • Antigen: PEAR1
  • Clone: REA790
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: MEGF12
  • Distribution of antigen: endothelial cells, platelets, heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain, megakaryocytes, osteoblasts, leukocytes, macrophages
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBright 515, Biotin
  • Selected references

    1. Nanda, N. et al. (2005) Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J. Biol. Chem. 280(26): 24680-24689
    2. Nanda, N. et al. (2006) Novel targets for antithrombotic drug discovery. Blood Cells Mol. Dis. 36(2): 228-231
    3. Herrera-Galeano, J. E. et al. (2008) A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability. Arterioscler. Thromb. Vasc. Biol. 28(8): 1484-1490
Product options: 8
for 30
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(1)
JPY 26,000
for 100
tests
(1)
JPY 62,000
for 30
tests
(1)
JPY 26,000
for 100
tests
(1)
JPY 62,000
for 30
tests
(1)
JPY 31,000
for 100
tests
(1)
JPY 75,000
for 30
tests
(1)
JPY 22,000
for 100
tests
(1)
JPY 52,000

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