Anti-NKG2A/C/E antibodies, mouse

Anti-NKG2A/C/E antibodies, mouse

Clone: 20d5 | Dilution: 1:10
Clone 20d5 recognizes the mouse NKG2A, NKG2C and NKG2E antigen on a subset of NK and NK-T cells in most mouse strains (e.g. AKR/J, BALB/c, C3H/He,C57BL/6, CBA/J, DBA/1, FVB/N, 129/Sv, NOD, SWR, and most DBA/2 substrains, but not DBA/2J). The C-type lectin-like NKG2 receptors form heterodimers of CD94 and one of several NKG2 family members, i.e., NKG2A (CD159a), NKG2C (CD159c), or NKG2E. CD94/NKG2 receptors monitor classical class I expression indirectly by means of the recognition of classical class I signal peptides. These signal peptides are processed to a nonamer peptide called Qdm that is presented to CD94/NKG2
+
NK cells by a nonclassical MHC class I molecule called Qa-1. CD94/NKG2 receptors equip NK cells with the capacity to detect cells with abnormal MHC class I expression, such as often results from viral infection or transformation.

Alternative names

KLRC1, CD159a, NKG2A, NKG2B, NKG2C1, KLRC2, NKG2E, KLRC3, CD159c

Technical specifications

  • Antigen: NKG2A/C/E
  • Clone: 20d5
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: KLRC1, CD159a, NKG2A, NKG2B, NKG2C1, KLRC2, NKG2E, KLRC3, CD159c
  • Entrez Gene ID: 16641
  • Molecular mass of antigen [kDa]: 28
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Foley, B. et al. (2012)
      Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C
      +
      natural killer cells with potent function.
      Blood 119(11): 2665-2674
    2. Lohwasser, S. et al. (1999) Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells. Eur. J. Immunol. 29(3): 755-761
    3. Silver, E. T. et al. (1999) Molecular cloning of mouse NKG2A and C. Immunogenetics 49(7-8): 727-730
Product options: 16
9 µg in 300 µL (1)
JPY 3,800
30 µg in 1 mL (1)
JPY 7,500
9 µg in 300 µL (1)
JPY 4,800
30 µg in 1 mL (1)
JPY 12,000
9 µg in 300 µL (1)
JPY 7,000
30 µg in 1 mL (1)
JPY 12,000
9 µg in 300 µL (1)
JPY 10,000
30 µg in 1 mL (1)
JPY 17,000
9 µg in 300 µL (1)
JPY 8,500
30 µg in 1 mL (1)
JPY 18,000
9 µg in 300 µL (1)
JPY 9,000
30 µg in 1 mL (1)
JPY 18,000
9 µg in 300 µL (1)
JPY 8,300
30 µg in 1 mL (1)
JPY 18,000
9 µg in 300 µL (1)
JPY 2,800
30 µg in 1 mL (1)
JPY 7,500

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